IMMUNOCYTOCHEMICAL LOCALIZATION OF GFAP IN HUMAN-BRAIN TUMORS - HISTOLOGIC AND INVITRO STUDIES

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 23  (3) , 173-185
Abstract
On the basis of studies utilizing antibody to GFAP (glial fibrillary acidic protein) in the indirect immunofluorescent and immunoperoxidase methods, the presence of GFAP in 5 astrocytomas, 1 ependymoma and 1 medulloblastoma was reported. The GFAP was evidenced on cryostat sections of frozen material and in short-term tissue culture. Five others tumors including 1 oligodendrocytoma, 1 choroid-plexus papilloma, 1 meningioma and 2 secondary sarcomas were negative. Possible applications of antibodies to GFAP for localization and therapy of brain tumors were considered.