The Role of Soft Connective Tissue in the Breakdown of Pig Articular Cartilage Cultivated in the Presence of Complement-Sufficient Antiserum to Pig Erythrocytes

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Abstract
1. Articular cartilage from the 3rd and 4th metacarpals of young pigs was maintained for 10 or 14 days in organ culture, in either control media or medium containing rabbit antiserum to pig red cells and rabbit serum complement (A-S + C′). 2. In the absence of soft connective tissue, A-S + C′ had no obvious effect on the explanted cartilage. 3. Soft connective tissue, either as invading marrow or as an adjacent explant of joint capsule, caused some loss of metachromatic material from neighbouring cartilage matrix in explants grown in control medium. 4. This effect was much exaggerated by A-S + C′. 5. The very fibrous transitional cartilage linking the articular cartilage with the periosteum and bone, was highly susceptible to the action of A-S + C′, and a broad subarticular zone became necrotic and lost most of its metachromasia during treatment. 6. When combined with capsular tissue, fibrous cartilage was even more drastically affected by A-S + C′. 7. Antiserum produced a slight effect on articular cartilage associated with soft connective tissue, in the absence of complement.

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