MECHANISM OF INSULIN-SECRETION AFTER ORAL GLUCOSE ADMINISTRATION .7. EXOCRINE PANCREATIC FUNCTION AND PLASMA-IRI IN DOGS WITH CHRONIC PANCREATIC FISTULAS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 35  (10) , 1293-1300
Abstract
During an i.v. glucose test, conscious dogs with exocrine pancreatic fistulas showed a reduction in the secretions of water, protein and of bicarbonate. This reduction is related to hyperglycemia and to the IRI [immunoreactive insulin] increase in the peripheral venous blood. After oral administration of glucose, a biphasic stimulation of the exocrine function was observed. During the first 15 min when insulin secretion increases independently of the blood glucose increase, all exocrine pancreatic functions are transiently stimulated. A 2nd peak of the exocrine secretions is observed when glucose absorption and insulin secretion are maximal.