Corneal wound healing following laser in situ keratomileusis (LASIK): a histopathological study in rabbits
Open Access
- 1 November 1999
- journal article
- research article
- Published by BMJ in British Journal of Ophthalmology
- Vol. 83 (11) , 1302-1305
- https://doi.org/10.1136/bjo.83.11.1302
Abstract
AIMS To investigate the histopathological changes of rabbit corneas after laser in situ keratomileusis (LASIK) and to evaluate the corneal wound healing process. METHODS A LASIK was performed on white rabbit eyes. Postoperatively, rabbits were killed on days 1 and 7, and at 1, 3, and 9 months. RESULTS Periodic acid Schiff (PAS) positive material and disorganised collagen fibre were seen along the interface of the corneal flap even 9 months after operation. CONCLUSIONS The wound healing process still continued at 9 months after LASIK indicating that a much longer time than expected was required for corneal wound healing following LASIK.Keywords
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