Abstract
Summary Studies on the interaction of two dopamine (DA) agonists (selected as most specific): apomorphine (APO) and 1, 3-dimethyl-5-aminoadamantane (DMAA) with serotonin (5-HT) and noradrenaline (NA) brain systems have revealed that the drugs induce the activation of 5-HT and NA neurons in an indirect way (via primary DA stimulation). These interactions are relevant for some pharmacological effects of DA agonists.