Ketoconazole Protects against Infection with Trypanosoma Cruzi in a Murine Model
- 1 September 1983
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 32 (5) , 960-962
- https://doi.org/10.4269/ajtmh.1983.32.960
Abstract
The oral administration of ketoconazole to mice protected them against death caused by infection with Trypanosoma cruzi. The addition of ketoconazole to cultures of macrophages infected with the organism markedly inhibited the intracellular multiplication of amastigotes. These observations suggest that ketoconazole may be a potent agent against T. cruzi and should be evaluated more extensively as a chemotherapeutic agent for Chagas' disease.This publication has 3 references indexed in Scilit:
- Imidazole and Polyene Activity Against Chloroquine-Resistant Plasmodium falciparumThe Journal of Infectious Diseases, 1981
- Isolation of the intracellular stage of Trypanosoma cruzi and its interaction with mouse macrophages in vitroInfection and Immunity, 1981
- Activity of Imidazoles Against Leishmania Tropica in Human Macrophage CulturesThe American Journal of Tropical Medicine and Hygiene, 1981