Immunohistochemical Detection of Proliferating Tumor Cells in Cervical Cancer Using Monoclonal Antibody Ki-67
- 1 January 1994
- journal article
- research article
- Published by S. Karger AG in Gynecologic and Obstetric Investigation
- Vol. 37 (2) , 123-126
- https://doi.org/10.1159/000292539
Abstract
Monoclonal antibody Ki-67 identifies cells in Gl, S, G2, and M phases of the cell cycle. In this cytokinetic study, Ki-67 was used to characterize tumor cells in human cervical cancer specimen. This immunohistochemical study showed that Ki-67 staining gave a brown nuclear reactivity dispersed heterogeneously in a tumor cell population and correlated well with the mitotic activities of tumor cells. The finding suggested that Ki-67 staining provides an easily countable index for the study of proliferating cell populations in cervical cancer.Keywords
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