Peripheral benzodiazepines potentiate the effect of adenosine in rat vas deferens
- 1 January 1991
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 43 (1) , 49-50
- https://doi.org/10.1111/j.2042-7158.1991.tb05448.x
Abstract
Ro 5–4864, diazepam, clonazepam and PK 11195 inhibit the responses of rat vas deferens following electrical stimulation in the rank order Ro 5–4864 > PK 11195 = diazepam > clonazepam. The adenosine-inhibited electrically-induced response was potentiated by Ro 5–4864 or diazepam, but not by clonazepam or PK 11195. This potentiation is due to an inhibition of the adenosine uptake system.Keywords
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