Control of DNA synthesis in polyploid mammalian cells
- 1 November 1984
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 121 (2) , 409-414
- https://doi.org/10.1002/jcp.1041210219
Abstract
To test the hypothesis that the duration of DNA synthesis is an inverse function of nuclear size or DNA content, the S phase was calculated from PLM analysis for pseudodiploid, tetraploid, and octaploid lines of Chinese hamster cells growing as a monolayer or in suspension. S phase times were found not to be significantly different between polyploid lines and the diploid lines from which they were derived, regardless of the conformation of the nucleus. There is no evidence, therefore, that would implicate the nuclear membrane, or nuclear surface area/volume relationships, in the control of DNA synthesis.This publication has 10 references indexed in Scilit:
- A fixed site of DNA replication in eucaryotic cellsCell, 1980
- Changes in the cell cycle during culture of mouse-Chinese hamster cell hybridsJournal of Cellular Physiology, 1980
- Cell Polyploidy: Its Relation to Tissue Growth and FunctionPublished by Elsevier ,1977
- Cell cycles and chromosome replication patterns in interspecific somatic hybridsExperimental Cell Research, 1972
- The Structure and Function of ChromatinPublished by Springer Nature ,1972
- Mutation rates in cells at different ploidy levelsJournal of Cellular Physiology, 1971
- A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMESThe Lancet, 1971
- EVIDENCE FOR CONTROL OF THE RATE OF NUCLEAR DNA SYNTHESIS BY THE NUCLEAR MEMBRANE IN EUKARYOTIC CELLSProceedings of the National Academy of Sciences, 1969
- Relationships between mitotic cycle duration, S period duration and the average rate of DNA synthesis in the root meristem cells of several plantsExperimental Cell Research, 1965
- A RELATIONSHIP BETWEEN DNA CONTENT, NUCLEAR VOLUME, AND MINIMUM MITOTIC CYCLE TIMEProceedings of the National Academy of Sciences, 1963