Effect of simultaneous administration of drugs on absorption and excretion. XIII. Effect of salicylic acid on the absorption, distribution and elimination of carbutamide in rabbits.

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Abstract
Salicylic acid reduced the in situ intestinal absorption of carbutamide [a hypaglycemic agent] and ehanced in situ carbutamide intestinal exsorption. Salicylic acid did not affect in vitro carbutamide intestinal absorption. Apparently, the displacement of carbutamide from its plasma protein binding sites by salicylic acid can become an important factor affecting the intestinal absorption of carbutamide in intact rabbits. Salicylic acid caused a significant increase in the apparent volume of distribution (Vd.beta.) and in the total body clearance (ClT) of carbutamide. Salicylic acid significantly increased the distribution of carbutamide into the pancreas and into the kidney. These findings may be explained on the basis of the displacement of carbutamide from its plasma protein binding sites by salicylic acid.

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