Correlation pKa – activité catalytique des thiols dans la réaction d'hydrolyse de l'acétate de p-nitrophényle
- 1 November 1984
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 62 (11) , 2330-2336
- https://doi.org/10.1139/v84-397
Abstract
The kinetic study of the hydrolysis of p-nitrophenylacetate in the presence of primary thiols indicates the thiolate anion as the sole catalytic species. Comparison of the true second order rate constants (kRS−) reveals that purely aliphatic primary thiols behave differently from aromatic α-substituted primary thiols. In the latter group a correlation can be established between the true second order rate constants and the pKSH values by means of the Brönsted equation log kRS− = βpKSH + C, with β equal to 0.40 and C equal to −0.85.This publication has 3 references indexed in Scilit:
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- A Kinetic Study of the Reaction of Thiols with p-Nitrophenyl Acetale*Biochemistry, 1964
- The Acid Strength of the -SH Group in Cysteine and Related CompoundsJournal of the American Chemical Society, 1955