Enzyme Synthesis in Synchronous Cultures
- 15 August 1969
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 165 (3894) , 657-663
- https://doi.org/10.1126/science.165.3894.657
Abstract
Neurogenic secretion of catecholamines from the adrenal medulla in rabbits, induced by administration of insulin, caused decreases in both the dopamine-β-hydroxylase activity and the catecholamine content of the storage vesicle fraction. After sedimentation through a sucrose density gradient, the storage vesicles obtained from insulin-treated animals had the same density and the same ratio of dopamine-β-hydroxylase to catecholamine as did vesicles from untreated animals. These and other data indicate that neurogenic secretion from the adrenal medulla occurs by an all-or-none release from the storage vesicles.Keywords
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