INTERACTION OF MORPHINE AND HYPOGLYCAEMIA IN STIMULATING THE RELEASE OF GROWTH HORMONE IN THE RAT

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Abstract
Unité de Neuroendocrinologie, INSERM – U.159, 2ter rue d'Alésia, 75014 Paris, France (Received 16 February 1977) It has been reported by Kokka, Garcia, George & Elliott (1972) and Martin, Audet & Saunders (1975) that morphine stimulates the release of growth hormone (GH) in the rat. Previous studies from this laboratory indicated that another narcoanalgesic, gamma-hydroxybutyrate (GHB), is able to stimulate immunoreactive GH secretion, but the pattern of this response differs markedly from that elicited by morphine (M. T. Bluet-Pajot & C. Schaub, unpublished results). We have also used GHB and eliminated stress effects to demonstrate that GH secretion in the rat can be induced by controlled hypoglycaemia as in primates (Bluet-Pajot, Schaub & Nassiet, 1976). In the present study we have investigated whether morphine could elicit a GH response under GHB narcoanalgesia, and whether GH secretion induced by spontaneous or provoked hypoglycaemia interfered with this effect. Automated blood glucose monitoring

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