Relationship between pancreozymin and cholinergic stimulation of pancreatic secretion

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Abstract
In conscious pancreatic-fistula dogs with low gastroenterostomies the interactions of pancreozymin (PZ) with methacholine were studied. Combinations of methacholine and PZ depressed amylase, lipase, and total protein secretion when doses were high, i.e. above 2 units/min PZ with 2 μg/min methacholine as background, and above 4 μg/min methacholine with 2 units/min PZ as background. Atropine depressed the enzyme response to Boots but not to Jorpes PZ. It did not alter the depression produced by high doses of PZ and methacholine in combination. These data are consistent with the view that the actions of PZ and methacholine on enzyme production are closely related.

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