THE INTERCONVERSION OF OESTRONE AND OESTRADIOL-17β AND THE CONCENTRATION OF OESTRADIOL-17β RECEPTORS IN CULTURED RABBIT UTERUS

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Abstract
SUMMARY: The metabolism and uptake of [2,4,6,7-3H]oestrone and [2,4,6,7-3H]oestradiol-17β were examined in explants of rabbit uterus, vagina and skeletal muscle in organ culture for 1 and 3 days. Irrespective of whether the uterus was cultured in the presence of [3H]oestrone or [3H]oestradiol-17β, the tissue contained predominantly [3H]oestradiol-17β. This was also true for vagina, but muscle showed only a limited ability to interconvert the two oestrogens. The oestradiol-17β binding capacity of cultured uterus was also determined, and was shown to decline rapidly over the first 24 h of culture.

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