Natural Distribution of Squirrel Monkey Retrovirus Proviral Sequences in Primate DNAs

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Abstract
3H-labeled 70S RNA of squirrel monkey retrovirus (SMRV) hybridized to a high degree (> 52%) to the DNA of various tissues of 2 squirrel monkeys. Hybridization of the same probe to DNA of other primates including New World monkeys (woolly monkey, capuchin, owl monkey), Old World monkeys (rhesus, African green), apes (gibbon, chimpanzee) and human (A204 cells infected with MPMV [Mason-Pfizer monkey virus]) revealed no significant hybridization. Analysis of the kinetics of hybridization indicated that SMRV provirus was present in multiple copies in various squirrel monkey tissues (C0t1/2 = 120-400) and in SMRV-infected A204 cells at a low number of copies (C0t1/2 = 1500). SMRV is an endogenous virus of squirrel monkeys and the 1st isolated from a New World monkey.

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