Hemmung der 3H-TdR-Aufnahme in Tumorzellen nach Zytostatikagabe als Ma therapeutischer Wirksamkeit
- 1 August 1981
- journal article
- research article
- Published by Springer Nature in Annals of Hematology
- Vol. 43 (2) , 105-107
- https://doi.org/10.1007/bf00320469
Abstract
In 36 Walker-ascites-carcinosarcoma bearing rats the reduction of 3H-TdR-incorporation into tumor cells after cytotoxic treatment as an potential prognostic factor for efficacy of chemotherapy was tested. Twelve rats each were i.p. treated with 1 mg/kg bw. DDP resp. 0.8 mg/kg bw. Adriamycin. Twelve rats were injected with 0.2 mg phys. NaCl and served as control. Survival of rats served as criterion of therapeutic efficacy. There was a significant correlation between reduction of 3H-TdR-uptake in tumor cells after cytotoxic therapy and survival.Keywords
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