Effect of intragastric pressure on gastric emptying and secretion.

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Abstract
In intact dogs the pressure in the main cavity of the stomach was held constant at various levels by a barostat, and intragastric pH was held at 7.0 by intragastric titration. When the fluid level of the barostat was varied between 10 and 25 cm above the dog''s xiphoid process, increasing intragastric pressure produced a linear increase in rate of gastric emptying. With an isotonic saline meal, emptying increased 1.2 ml min-1 cm-1 in pressure. Increases in intragastric pressure produced significantly greater increases in emptying rate and significantly smaller increases in gastric volume with a meal of isotonic saline than with isotonic liver extract. Increases in intragastric pressures increased acid secretion (to 39% of the maximal response to gastrin) with the saline meal but had no effect on acid secretion with the liver extract meal (85% of maximal response to gastrin). Infusion of gastrin at a dose that produced maximal acid secretion had no effect on emptying or gastric volume, whereas infusion of octapeptide of cholecystokinin in a dose that produces half-maximal pancreatic protein secretion significantly inhibited emptying and increased gastric volume. The pressure in the main cavity of the stomach has a marked effect on the rate of gastric emptying of liquid meals, but other factors also operate.