VARIATION OF MECHANICAL AND BIOCHEMICAL PARAMETERS OF PRESSURE-LOADED RABBIT HEARTS FOLLOWING CHRONIC ADMINISTRATION OF DIPYRIDAMOLE

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  • 1 January 1975
    • journal article
    • research article
    • Vol. 34  (11-1) , 1895-1905
Abstract
After constricting the aorta ascendens of rabbits, the influence of chronic of dipyridamole (8 mg/kg i.m. on 6 of 7 days of the wk for 3 mo.) administration upon heart hypertrophy, hemodynamics and the hydroxyproline content in the right and left ventricles and the incorporation rate of 2-[14C]-glycine into the actomyosin and soluble protein of the left ventricle was studied. The dipyridamole treatment had no effect on the increase in systolic pressure, the contractility index of the aorta-stenosed animals and heart rate. The hypertrophic development, and consequently the increase in hydroxyproline concentration and the increased incorporation rate of 2-[14C]-glycine into the soluble protein were inhibited. The possible mechanism of action of dipyridamole on the development of heart hypertrophy in the rabbit is discussed.