A Lymphoblastoid Response of Human Foetal Lymphocytes to Ultraviolet-irradiated Herpes Simplex Virus

Publisher Website
Google Scholar
Abstract
Cultures of fetal lymphocytes were exposed to UV-irradiated herpes simplex virus (HSV). The cells responded with increased 6-3H-thymidine incorporation, the formation of clumps of enlarged lymphoblastoid cells and cell division. This response was first detected 3-4 days after exposure to virus material and was virus-dose dependent. The ability to stimulate fetal cells was considerably more UV resistant than infectivity. Two isolates of HSV type 2 (4663 and 37174), which had a high transforming ability, produced large numbers of noninfectious particles (particle: infectivity ratios in excess of 104). The cells, which responded to UV-irradiated HSV with blastoid transformation, were associated with the non-E-rosetting (T[thymus-derived]cell-depleted) subpopulation.

This publication has 0 references indexed in Scilit: