TETRAETHYLTHIURAMDISULFIDE (ANTABUSE®) THERAPY

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Abstract
About two years ago reports began to appear in the medical literature on the use of a substance, tetraethylthiuramdisulfide, more popularly known as antabuse.® The ingestion of this substance appeared to sensitize persons to the use of alcohol. In a patient receiving as little as 500 mg. of tetraethylthiuramdisulfide daily, the ingestion of 30 cc. or more of gin or its alcoholic equivalent will shortly be followed by symptoms that include a feeling of heat in the face and intense flushing of the face, and sometimes of the neck and chest. Probably the most characteristic effect is dilatation of the scleral vessels. A little later, palpitation and dyspnea develop, and in severe cases nausea and vomiting occur. These symptoms usually disappear within a few hours, leaving the person rather sleepy. Production of the above-described symptoms depends upon the fact that in the presence of tetraethylthiuramdisulfide considerable quantities of alcohol are

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