CD30(Ki-1) Antigen Expression in a Subset of Gastric Mucosal Plasma Cells and in a Primary Gastric Plasmacytoma

Publisher Website
Google Scholar
Abstract
With the use of frozen sections, 24 different monoclonal antibodies (MoAbs), and an indirect peroxidase technique, the antigenic profile of a well-differentiated primary gastric plasma-cytoma was obtained. Corresponding to the normal plasma cell, tumor cells were devoid of HLA-D products and B-cell–restricted differentiation antigens CD19, CD20, CD21, CD22, and CD23 while expressing plasma cell–associated CD24 and CD38 molecules and IgA/λ. The plasmacytoma furthermore reacted with CD30(Ki-1), a reactivity that for this tumor type has not been reported before. Subsequently, normal gastric mucosae affected by all degrees of chronic gastritis were examined. On the basis of serial sections, 5–15% of CD38(OKT10) reactive mucosal plasma cells were observed to also react with CD30(Ki-1). The authors conclude that the CD30 antigen is not only an activation antigen but is also expressed on a subset of terminally differentiated plasma cells.

This publication has 0 references indexed in Scilit: