Contributions to the Regulatory Role of Insulin in Inflammation and Anaphylaxis

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Abstract
Insulin, in doses which did not influence the blood sugar level, potentiated the anaphylactic shock in ovalbumin-sensitized CFLP mice and moderatedly inhibited the carrageenan-induced paw edema. Higher doses were found to produce a dose-dependent inhibition of the inflammatory process at the 2nd hour, and caused less suppression at the 4th hour of the swelling. These results suggest that insulin may play a complex regulatory role in hypersensitivity and inflammatory reactions, and its effect is not necessarily related to hypoglycemia.

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