Genotypesof Pneumocystis jiroveci Isolates Obtained in Harare,Zimbabwe, and London, UnitedKingdom
Open Access
- 1 December 2003
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (12) , 3979-3981
- https://doi.org/10.1128/aac.47.12.3979-3981.2003
Abstract
Isolates of Pneumocystis jiroveci from sulfa-exposed and nonexposed patients from London, United Kingdom, and Harare, Zimbabwe, were genotyped. At the dihydropteroate synthase (DHPS) locus, there was evidence of selection pressure from sulfa drug exposure, and reversal of DHPS genotype ratios occurred when selection pressure was absent or was removed.Keywords
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