Highly Stereoselective Formal [3 + 3] Cycloaddition Reactions of Chiral Vinylogous Amides with α,β-Unsaturated Iminiums
- 18 March 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (8) , 1161-1164
- https://doi.org/10.1021/ol000049+
Abstract
Highly stereoselective formal [3 + 3] cycloaddition reactions of chiral vinylogous amides with α,β-unsaturated iminiums are described. A mechanistic model is proposed to rationalize the observed stereoselectivity. The 6π-electron electrocyclic ring closure appears to be reversible, and a preferred rotation of the alkenyl group, one of the three 2π-components, during the ring closure step provides the thermodynamically favored diastereomer as the major product.Keywords
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