INHIBITION OF OVARIAN AND TESTICULAR STEROIODOGENESIS BY EPIDERMAL GROWTH FACTOR
- 1 May 1981
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 108 (5) , 2002-2004
- https://doi.org/10.1210/endo-108-5-2002
Abstract
Epidermal growth factor (EGF), but not fibroblast growth factor, inhibits the gonadotropin stimulation of estrogen and testosterone production by primary cultures of ovarian granulosa and testicular Leydig cells, respectively. EGF also inhibits gonadal steroidogenesis induced by cholera toxin and (Bu)2cAMP, and the inhibitory effect of EGF is not associated with cell proliferation. EGF may play an important endocrine role in the regulation of steroidogenic functions of gonadal cells.Keywords
This publication has 1 reference indexed in Scilit:
- A comparison of the binding of epidermal growth factor to cultured granulosa and luteal cells.Journal of Biological Chemistry, 1978