Heterogeneity of 5-HT Receptors Mediating Secretion in the Human Intestine
- 1 May 1997
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 812 (1 Receptor) , 224-225
- https://doi.org/10.1111/j.1749-6632.1997.tb48183.x
Abstract
In conclusion, application of 5-HT has been shown to induce fluid secretion in both the small and large intestine of man. By the use of selective antagonists, the receptors mediating these effects have been identified and characterized. 5-HT induces secretion across human ileal mucosa via a receptor of the 5-HT4 sub-type, whereas a receptor of the 5-HT2A sub-type appears to mediate the effect in human sigmoid colon. The response in human ascending colonic mucosa cannot be definitively classified at this time, but may reflect the presence of a heterogenous receptor population.Keywords
This publication has 1 reference indexed in Scilit:
- Neurohormonal Control of Fluid and Electrolyte Transport in Intestinal MucosaPublished by American Geophysical Union (AGU) ,1991