SELECTIVE POTENTIATION OF HYPERTHERMIC KILLING OF HYPOXIC CELLS BY 5-THIO-D-GLUCOSE

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (9) , 2935-2938
Abstract
The modification of cell lethality at elevated temperatures by 5-thio-D-glucose, the nearest analog of D-glucose, was studied with the use of [human cervical carcinoma] HeLa cells in the presence or absence of oxygen. When the cells were exposed to temperatures ranging from 40.5-42% (c) for 0.5 to 4 h in the presence of 5-thio-D-glucose (5 mM), there was a selective potentiation of hyperthermic killing of hypoxic cells. No enhanced killing of oxic cells by 5-thio-D-glucose was seen at these temperatures. Glucose metabolism may be involved in influencing the heat sensitivity of hypoxic cells. The low toxicity of 5-thio-D-glucose and its specificity to hypoxic cells suggest that it may be a useful adjuvant to hyperthermic therapy.