Inhibition of procollagen cell-free synthesis by amino-terminal extension peptides
- 1 October 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 18 (22) , 5030-5034
- https://doi.org/10.1021/bi00589a034
Abstract
Peptides prepared from the amino termini of pro .alpha.1(I) and pro .alpha.1(III) collagen chains inhibit the production of pro .alpha.1(I) and pro .alpha.2 by rat calvaria RNA in a reticulocyte cell-free system. The synthesis of other proteins was not altered, suggesting a specific effect on collagen production. Various peptides from the helical region of the .alpha.1(I) chain did not alter translation. Apparently there is a regulatory function in collagen synthesis for the amino-terminal peptides from procollagen.This publication has 12 references indexed in Scilit:
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