The factor VIII Structure and Mutation Resource Site: HAMSTeRS version 4
- 1 January 1998
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 26 (1) , 216-219
- https://doi.org/10.1093/nar/26.1.216
Abstract
Since 1996 the HAMSTeRS (Haemophilia A Mutation, Search, Test and Resource Site) WWW site has provided an online resource for access to data on the molecular pathology of haemophilia A, replacing previous text editions of the Haemophilia A Database published in Nucleic Acids Research . This report describes the continued development of the site (version 4), and in particular the expansion of factor VIII (FVIII) structure-related features. Access to the mutation database itself, both for searching the listings and for submission of new mutations, is via custom-designed forms: more powerful Boolean searches of the point mutations in the database are also available. During 1997 a total of 22 novel missense mutations were reported, increasing the total number of unique variants now described to 252 (238 in exonic sequences and 14 at intronic splice junctions). Currently, a total of 586 individual reports with associated phenotypic data are available for searching by any category including phenotype. The FVIII structure section now includes a download of a FVIII A domain homology model in Protein Data Bank format and a multiple alignment of the FVIII amino-acid sequencies from four species (human, murine, porcine and canine) in addition to the virtual reality simulations, secondary structural data and FVIII animation already available. Finally, to aid navigation across this site, a clickable roadmap of the main features provides easy access to the page desired. Our intention is that continued development and updating of the site shall provide workers in the fields of molecular and structural biology with a one-stop resource site to facilitate FVIII research and education. The HAMSTeRS URL is http://europium.mrc.rpms.ac.ukKeywords
This publication has 13 references indexed in Scilit:
- The Factor VIII Mutation Database on the World Wide Web: The Haemophilia A Mutation, Search, Test and Resource Site HAMSTeRS Update (version 3.0)Nucleic Acids Research, 1997
- The cDNA and derived amino acid sequence of porcine factor VIII.1996
- The haemophilia A mutation search test and resource site, home page of the factor VIII mutation database: HAMSTeRSNucleic Acids Research, 1996
- X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B.Proceedings of the National Academy of Sciences, 1995
- Molecular etiology of factor VIII deficiency in hemophilia AHuman Mutation, 1995
- Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second editionNucleic Acids Research, 1994
- Factor VIIIa A2 subunit residues 558-565 represent a factor IXa interactive site.Journal of Biological Chemistry, 1994
- Sequence of the Murine Factor VIII cDNAGenomics, 1993
- Haemophilia A: database of ncleotide substituttions, deletions, insertions and rearrangements of the factor VIII geneNucleic Acids Research, 1991
- Molecular cloning of a cDNA encoding human antihaemophilic factorNature, 1984