Effect of Vigabatrin on the Electroencephalogram in Rats

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Abstract
Summary: Vigabatrin (γ‐vinyl GABA; GVG) is a new antiepileptic drug (AED) that increases the level of the inhibitory transmitter, γ‐aminobutyric acid (GABA) in the brain. We evaluated the effect of GVG on the EEG of normal rats. GVG was administered intraperitoneally (i.p.) at a dose of 100 mg/kg once a day for 12 days. EEG was recorded at baseline, on the fourth day, at the end of the 12‐day GVG period and 10 days after discontinuation of GVG. GVG increased the amplitude of delta (1–4 Hz) and theta (4–8 Hz) frequency bands and resulted in slowing of the peak frequency (F) and mean frequency (Fp) in both the frontal and occipital cortex, especially during waking‐immobility. EEG changes normalized within 10 days after the last GVG injections. The results suggest that a relationship may exist between the EEG changes and increase in GABA levels with GVG.