AUTOIMMUNE-THYROIDITIS - CONVERSION OF LOW-RESPONDER MICE TO HIGH-RESPONDERS BY CYCLOPHOSPHAMIDE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 47  (3) , 683-688
Abstract
Inbred strains of mice are low- or high-responders with resepect to the magnitude of thyroid infiltrates that appear after immunization with mouse thyroglobulin emulsified in Freund''s complete adjuvant. This aspect of the immune response to thyroglobulin is strongly controlled by the major histocompatibility complex. Low-responder strains treated with cyclophosphamide, before the antigenic challenge, were converted to high-responders. In low-responder mice, a specific suppressor activity probably influences the development of the thyroid lesions characteristic for the autoimmune thyroiditis.