Biosynthesis of the polyether antibiotic monensin A: incorporation of a polyketide chain elongation intermediate
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 16,p. 1258-1260
- https://doi.org/10.1039/c39930001258
Abstract
Evidence that the polyether antibiotic monensin A is constructed by a processive strategy of polyketide assembly has been obtained by the specific incorporation of labelled 5-oxo-2,4-dimethylhexanoate, activated as an acetylcysteamine thioester, into the antibiotic in shake cultures of Streptomyces cinnamonensis: crucial to the successful incorporation are the presence of 2,6-O-dimethyl-β-cyclodextrin and a β-oxidation inhibitor during the fermentation.Keywords
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