PERIODIC ACID SCHIFF-POSITIVE NON-GLYCOGENIC GLOBULES IN HEPATOCYTES - DIFFERENTIAL DIAGNOSTIC ASPECTS IN SCREENING FOR ALPHA-1-ANTITRYPSIN GLOBULES IN AN AUTOPSY MATERIAL

  • 1 January 1978
    • journal article
    • research article
    • Vol. 86  (4) , 325-329
Abstract
In 238 autopsies, 38 subjects with diastase-resistant periodic acid Schiff-positive cytoplasmic globules in hepatocytes were found. In 15 of the 38 subjects the globules were antigenically alpha-1-antitrypsin, in 23 subjects they were not. The latter globules were found in centrilobular regions, the alpha-1-antitrypsin globules mainly in periportal regions. The non-alpha-1-antitrypsin globules showed less difference in size (6-10 .mu.) and a smaller number/hepatocyte (1-7) than the alpha-1-antitrypsin globules (1-40 .mu. and 1-30/cell). The non-alpha-1-antitrypsin globules were only demonstrated in livers with centrilobular sinusoidal dilatation having, in all cases but one, also centrilobular, confluent necrosis. This type of globule is probably of differential diagnostic importance mainly in autopsy material. The nature of these globules is discussed.

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