Syntheses of Peptides Related to the N-Terminal Structure of Corticotropin. V. Synthesis of the Peptide Fragments, His-Phe-Arg-Try, His-Phe-Arg-Try-Gly and Glu-His-Phe-Arg-Try-Gly
- 1 July 1965
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 38 (7) , 1148-1157
- https://doi.org/10.1246/bcsj.38.1148
Abstract
1) Synthesis of the peptides l-histidyl-l-phenylalanyl-l-arginyl-l-tryptophan, l-histidyl-l-phenylalanyl-l- arginyl -l-tryptophyl-glycine and l-glutamyl-l-histidyl-l-phenylalanyl-l-arginyl-l-tryptophyl-glycine, which corresponded to the amino acid sequences of positions 6–9, 6–10 and 5–10, respectively, of the corticotropin and α-MSH molecules, has been described. 2) The synthetic procedure for γ-t-butyl-l-glutamyl-l-histidyl-l-phenylalanlyl-l-arginyl-l-tryptophyl-glycine, a key intermediate to the higher peptides eliciting the adrenocorticotropic activity, has been improved. 3) An active ester Nα, NIm-dicarbobenzoxy-l-histidine p-nitrophenyl ester has been found to be of value for the synthesis of histidyl peptides. 4) An effective use of partition chromatography on a Sephadex column for purification of peptides has been cited.This publication has 21 references indexed in Scilit:
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