The possible use ofTrypanosoma musculi infection in mice as a screening test for potentialTrypanosoma cruzi-active drugs

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Abstract
The ability of a range of trypanocidal drugs, including a number known to be active inTrypanosoma cruzi infections were tested againstTrypanosoma musculi infections in the mouse. The ability of these drugs, particularly in their ability to eliminate the “cryptic phase” ofT. musculi infections remaining in the kidneys, was investigated and their activity against this phase ofT. musculi largely paralleled their known activity againstT. cruzi infections. It is suggested that this could be used as a preliminary screening test for potentialT. cruzi-active drugs.

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