Synthesis and secretion of Alzheimer amyloid βA4 precursor protein by stimulated human peripheral blood leucocytes
Open Access
- 17 December 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 277 (1-2) , 261-266
- https://doi.org/10.1016/0014-5793(90)80861-c
Abstract
Alzheimer amyloid precursor proteins (APP) are actively secreted by stimulated human peripheral mononuclear blood leucocytes (PMBLs). Induction of APP transcription, translation and secretion was observed with several T cell mitogens but was highest with phytohemagglutinin. The time course of induction is similar to that reported for IL‐2 and IL‐2 receptor. We suggest that APP may play an important role in the construction of the immunological network and the differentiation of T cells.Keywords
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