Light and Scanning Electron Microscopy of Nasal Biopsy Material from Patients with Naturally Acquired Common Colds

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Abstract
As knowledge of histopathology of common colds is very limited, a blind quantitative examination by scanning electron microscopy and light microscopy was undertaken of 56 nasal biopsies taken from 29 volunteers with naturally acquired colds. In agreement with earlier reports there was evidence of sloughing of epithelial cells, but, in contrast to in vitro experiments, this did not result in a destruction of the epithelial lining, which by and large remained continuous with structurally normal cell borders. There was a significant increase in the number of neutrophils, in epithelium and in lamina propria, already on the 2nd day of the disease. The virus infection itself may be the cause of the local neutrophilia. The only other abnormality demonstrated was an increased number of extracellular erythrocytes in the acute stage. Histological picture was not suggestive of an involvement of epithelial mast cells in the inflammation.