Biomolecular dynamics and electron spin resonance spectra of copper complexes of antitumour agents in solution

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Abstract
For the purpose of developing new antitumour agents which are more efficacious and have less generalized toxicity than existing ones, the free-radical generation and metal complexation of well known anticancer agents have been studied. Copper(II) ion complexes are readily formed with several members of a class of hydroxyurea derivatives which are known to be effective ribonucleotide reductase inhibitors. E.s.r. measurements and u.v.–visible titration illustrate weak binding for 3,4-dihydroxybenzohydroxamic acid and tight binding in complex formation for gallohydroxamic acid and 2,3,4-trihydroxybenzohydroxamic acid. These data were used in a preliminary investigation of cytotoxicity, and the results are consistent with single phase cell cycle killing.

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