The correlation of susceptibility of differentPropionibacterium strains to macrophage killing and antitumor activity

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Abstract
The stimulation of the reticuloendothelial system and antitumor activity againstsarcoma-L-1 of three different strains ofPropionibacterium was investigated. The bacteria injected intraperitoneally with a single dose of 1 mg per mouse appeared to possess different effectiveness in both assays used. The same strains were examined for their susceptibility to phagocytosis and intracellular killing by murine peritoneal macrophages. The results obtained showed correlations betweenPropionibacterium resistance to degradation by phagocytic cells and their antitumor and stimulatory activities. It is concluded that the potency of antitumor and stimulatory activities of different strains ofPropionibacterium are closely related to their cell wall structure.