Expression of peroxisome‐proliferator activated receptor‐gamma (PPARγ) and the PPARγ co‐activator, PGC‐1, in human breast cancer correlates with clinical outcomes
Open Access
- 18 June 2003
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 106 (5) , 752-757
- https://doi.org/10.1002/ijc.11302
Abstract
Peroxisome‐proliferator activated receptor‐gamma (PPARγ) belongs to a family of nuclear receptors and acts as receptor for peroxisome‐proliferators, steroids, retinoic acids, and polyunsaturated fatty acids. Our study examined the transcript levels of peroxisome‐proliferator activated receptor‐gamma (PPARγ) and its co‐activator (PGC‐1) in a cohort of patients with breast cancer. An invasive breast cancer cell, MDA MB 231 exhibited lower level of expression of PPARγ, compared to non‐invasive MCF‐7. Breast cancer tissues (n = 120) exhibited a lower level of PPARγ mRNA compared to normal tissues (n = 25, p = 0.05). No difference, however, was seen with PGC‐1. Although the levels of PPARγ and PGC‐1 did not correlate with nodal involvement and grade, significantly lower levels of PPARγ were seen in TNM3 and TNM4 tumors and from patients with local recurrence and those who died of breast cancer. Lowest level of PGC‐1 was also seen in TNM3 and TNM4 tumors and patients who died of breast cancer. We conclude that there is aberrant expression of PPARγ and its co‐activator, PGC‐1, in human breast cancer and low levels of these molecules in cancer tissues are associated with poor clinical outcomes.Keywords
This publication has 34 references indexed in Scilit:
- Lymphangiogenesis Quantification Using Quantitative PCR and Breast Cancer as a ModelBiochemical and Biophysical Research Communications, 2001
- Inhibition of Cellular Proliferation through IκB Kinase-Independent and Peroxisome Proliferator-Activated Receptor γ-Dependent Repression of Cyclin D1Molecular and Cellular Biology, 2001
- Troglitazone, a Ligand for Peroxisome Proliferator‐activated Receptor γ Inhibits Chemically‐induced Aberrant Crypt Foci in RatsJapanese Journal of Cancer Research, 2001
- PPAR-γ Is Selectively Upregulated in Caco-2 Cells by ButyrateBiochemical and Biophysical Research Communications, 2000
- Peroxisome proliferator activated receptor-γ (PPAR-γ) mediates the action of gamma linolenic acid in breast cancer cellsProstaglandins, Leukotrienes & Essential Fatty Acids, 2000
- Cloning and mRNA tissue distribution of human PPARγ coactivator-1International Journal of Obesity, 1999
- PPARγ Inhibits the Expression of c-MET in Human Gastric Cancer Cells through the Suppression of EtsBiochemical and Biophysical Research Communications, 1999
- Human Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 (PPARGC1) Gene: cDNA Sequence, Genomic Organization, Chromosomal Localization, and Tissue ExpressionGenomics, 1999
- The ontogeny of peroxisome-proliferator-activated receptor gene expression in the mouse and ratProceedings Of The Royal Society B-Biological Sciences, 1992
- Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferatorsNature, 1990