Toxicity of Crataegus (Hawthorn) Extract (WS 1442)

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Abstract
An extract of Crataegus-WS 1442-standardized by a special process of production and adjusted to 18.75% oligomeric procyanidines, was investigated in single and repeat-dose toxicity studies. No target organ toxicity was defined at high multiples of the human dose (100 times) and the battery of standard mutagenic and clastogenic tests were negative. The results presented are for Crataegus extract WS 1442 only; other preparations of Crataegus have to be investigated case by case.