Malignant glioma: Who benefits from adjuvant chemotherapy?
- 8 October 1998
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 44 (4) , 691-695
- https://doi.org/10.1002/ana.410440418
Abstract
We combined two randomized prospective Brain Tumor Study Group data sets to analyze the effects of prognostic factors on survival by treatment group. Adjuvant chemotherapy increased long-term survival regardless of prognostic factors. Pathological review revealed that oligodendrogliomas were overrepresented among long-term survivors independent of therapy. Prognostic factors do not predict benefit from adjuvant nitrosourea in malignant gliomas, and long-term survival with chemotherapy is not explained by oligodendroglial tumors.Keywords
This publication has 9 references indexed in Scilit:
- Age influences chemotherapy response in astrocytomasNeurology, 1995
- Shared Allelic Losses on Chromosomes 1p and 19q Suggest a Common Origin of Oligodendroglioma and OligoastrocytomaJournal of Neuropathology and Experimental Neurology, 1995
- Chemotherapy for anaplastic oligodendroglioma. National Cancer Institute of Canada Clinical Trials Group.Journal of Clinical Oncology, 1994
- Long-Term Survival in Patients with Malignant AstrocytomaNeurosurgery, 1994
- Recursive Partitioning Analysis of Prognostic Factors in Three Radiation Therapy Oncology Group Malignant Glioma TrialsJNCI Journal of the National Cancer Institute, 1993
- Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adultsCancer, 1993
- Steroid‐induced CT changes in patients with recurrent malignant gliomaNeurology, 1988
- Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint radiation therapy oncology group and eastern cooperative oncology group studyCancer, 1983
- Randomized Comparisons of Radiotherapy and Nitrosoureas for the Treatment of Malignant Glioma after SurgeryNew England Journal of Medicine, 1980