Fatty acid biosynthesis in wallerian degeneration of rat sciatic nerve
- 1 September 1979
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 2 (5) , 369-375
- https://doi.org/10.1002/mus.880020508
Abstract
In‐vitro fatty acid biosynthesis was studied in normal rat sciatic nerve and during wallerian degeneration. Normal nerve incorporated 1,3‐C14‐malonyl‐CoA and 1‐C14‐acetyl‐CoA into fatty acids by a de‐novo biosynthetic pathway. The reaction product with highest radioactivity was palmitic acid, and the free fatty acids of nerve contained 90% of the total fatty acid label. During wallerian degeneration, there was a rapid increase of fatty acid biosynthesis that reached a peak between 16 and 24 days after nerve section. Values declined to normal levels at approximately 50 days.This publication has 14 references indexed in Scilit:
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