BLOOD FLOW IN THE CIRCUMFLEX BRANCH OF THE LEFT CORONARY ARTERY OF THE INTACT DOG

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Abstract
By the use of the thermostromuhr of Rein, expts. were made on the blood flow in the circumflex branch of the left coronary artery of the intact dog. Observations have been made over periods as long as 14 days. Epineph-rine causes a transient but marked increase in coronary blood flow amounting in some expts. to as much as 4 or 5 times the control values. The coronary blood flow is doubled by administration of nitroglycerine or amyl nitrite, but the effect is of short duration. In response to appropriate doses of thyroxin, increases in coronary flow as great as 244% above the control values were observed 48 to 96 hours after injection. During the digestion of a meat meal the coronary flow was increased to a degree comparable to what has been observed in other vessels of the body. Exercise on a treadmill produced an initial rapid augmentation in coronary flow, which declined to a lower level as the exercise continued, but additional work induced by changing the angle of the treadmill again caused a temporary increase in coronary flow, which declined to a lower value as the same degree of exercise continued. A significant correlation between heart weight and coronary flow or between pulse rate and coronary flow was not found.

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