Melanocyte Growth Factor in Normal Human Skin
- 1 February 1991
- journal article
- research article
- Published by Wiley in Pigment Cell Research
- Vol. 4 (1) , 48-51
- https://doi.org/10.1111/j.1600-0749.1991.tb00313.x
Abstract
Normal human skin is shown to contain melanocyte growth factor (MeGF). We found MeGF activity in extracts of both the epidermal portion of skin and the dermal portion. This activity was completely adsorbed onto heparin beads and eluted by 2.5 M NaCl. In addition, the activity of both extracts was completely blocked by antibodies directed against basic fibroblast growth factor (bFGF). It is suggested that melanocytes in epidermis are supported by bFGF-like MeGF in normal human skin.Keywords
This publication has 14 references indexed in Scilit:
- Regulation of Human Melanocyte Growth, Dendricity, and Melanization by Keratinocyte Derived FactorsJournal of Investigative Dermatology, 1989
- Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes.The Journal of cell biology, 1988
- Growth stimulation of human melanocytes: Identification and characterization of melanoma-derived melanocyte growth factor (M-McGF)Biochemical and Biophysical Research Communications, 1987
- Fibroblast growth factor: Structural and biological propertiesJournal of Cellular Physiology, 1987
- Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growthNature, 1987
- The stimulation of normal human melanocyte proliferation in vitro by melanocyte growth factor from bovine brainJournal of Cellular Physiology, 1985
- Ultraviolet Radiation Induces Changes in Membrane Metabolism of Human Keratinocytes in CultureJournal of Investigative Dermatology, 1984
- The control of embryonic pigment cell proliferation in culture by cyclic AMPDevelopmental Biology, 1982
- Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin.Proceedings of the National Academy of Sciences, 1982
- Mitotic Activity of Epidermal Melanocytes in Uv-Irradiated Mouse SkinJournal of Investigative Dermatology, 1978