Subcutaneous Carcinogenesis by Implants and by 7,12-Dimethylbenz[a]Anthracene

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Abstract
The effects of the combined administration of urethan or Trypan Blue to the s.c. injection of 7,12-dymethylbenz[a]anthracene (DMBA) were investigated. The repeated administration of Trypan Blue resulted in a marked inhibition of sarcomas arising around Teflon disc implanted s.c. It was thus confirmed, in a different strain of mice, the result of a previous experiment, where Trypan Blue was shown to exert an inhibiting action on the sarcoma production by glass fragments implanted subcutaneously. No consistent inhibiting action of Trypan Blue on the sarcoma production by DMBA could be demonstrated. Urethan administered before, concurrently or at various time after DMBA administration had no apparent effect on the incidence of sarcomas induced by DMBA. In a previous experiment urethan was showed to enhance the incidence of sarcomas arising around Teflon films.