Herpesvirus infections in the acquired immune deficiency syndrome

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Abstract
Herpesvirus infections were studied in persons with or at risk for the acquired immune deficiency syndrome (AIDS). The infections diagnosed were as follows: patients with AIDS, cytomegalovirus (CMV) in 34 of 34, Epstein-Barr virus (EBV) in 33 of 34, herpes simplex viruses (HSV) in 8 of 34, and varicella-zoster virus in 4 of 34: patients with chronic lymphadenopathy syndrome, CMV in 8 of 9 and EBV in 9 of 9; in healthy homosexual men, CMV in 5 of 13 and EBV in 7 of 8. Cytomegalovirus infections were frequently related to disease and death. Herpesvirus infections are frequent causes of serious diseases in AIDS. The prevalence of EBV and CMV infections in AIDS and the chronic lymphadenopathy syndrome may be the result of an important interaction between these viruses and the cause of AIDS.