Gosha‐jinki‐gan (a Herbal Complex) Corrects Abnormal Insulin Signaling
Open Access
- 1 January 2000
- journal article
- website
- Published by Wiley in Evidence-Based Complementary and Alternative Medicine
- Vol. 1 (3) , 269-276
- https://doi.org/10.1093/ecam/neh028
Abstract
Previous studies have shown that the traditional herbal complex Gosha-jinki-gan (GJG) improves diabetic neuropathy and insulin resistance. The present study was undertaken to elucidate the molecular mechanisms related with the long-term effects of GJG administration on insulin action in vivo and the early steps of insulin signaling in skeletal muscle in streptozotocin (STZ) diabetes. Rats were randomized into five subgroups: (1) saline treated control, (2) GJG treated control, (3) 2-unit insulinKeywords
Funding Information
- Ministry of Health, Labor and Welfare, Japan
This publication has 43 references indexed in Scilit:
- Cinnamon Extract Prevents the Insulin Resistance Induced by a High-fructose DietHormone and Metabolic Research, 2004
- Antinociceptive Mechanism of Gosha-jinki-gan in Streptozotocin-Induced Diabetic Animals: Role of Nitric Oxide in the PeripheryThe Japanese Journal of Pharmacology, 1999
- Effect of Gosha-jinki-gan, a Kampo Medicine, on Enhanced Platelet Aggregation in Streptozotocin-Induced Diabetic RatsThe Japanese Journal of Pharmacology, 1998
- Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.Journal of Clinical Investigation, 1995
- Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 geneNature, 1994
- Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1Nature, 1994
- Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.Journal of Clinical Investigation, 1993
- Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.Journal of Clinical Investigation, 1992
- Pathogenesis of NIDDM: A Balanced OverviewDiabetes Care, 1992
- Isoliquiritigenin: A New Aldose Reductase Inhibitor from Glycyrrhizae RadixPlanta Medica, 1990