Radiation-induced injury of the esophagus.

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Abstract
Patients (40) with functional or morphologic esophageal abnormalities following radiotherapy were identified. Abnormalities included abnormal motility with and without mucosal edema, stricture, ulceration, pseudodiverticulum and fistula. Abnormal motility occurred 4-12 wk following radiotherapy alone and as early as 1 wk after therapy when concomitant chemotherapy was given. Strictures developed 4-8 mo. following completion of radiotherapy. Ulceration, pseudodiverticulum and fistula formation did not develop in a uniform time frame. Radiation-induced esophageal injury is more frequent when radiotherapy and chemotherapy are combined than it is with radiotherapy alone.

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